High-performance computing (HPC) uses supercomputers and computer clusters to solve advanced computation problems. Today, computer systems approaching the teraflops-region are counted as HPC-computers.

The term is most commonly associated with computing used for scientific research. A related term, high-performance technical computing (HPTC), generally refers to the engineering applications of cluster-based computing (such as computational fluid dynamics and the building and testing of virtual prototypes). Recently, HPC has come to be applied to business uses of cluster-based supercomputers, such as data warehouses, line-of-business (LOB) applications, and transaction processing.

High-performance computing (HPC) is a term that arose after the term “supercomputing.” HPC is sometimes used as a synonym for supercomputing; but, in other contexts, “supercomputer” is used to refer to a more powerful subset of “high-performance computers,” and the term “supercomputing” becomes a subset of “high-performance computing.” The potential for confusion over the use of these terms is apparent.